Base de dados : HANSEN
Pesquisa : MYCOBACTERIUM LEPRAE/PATOGENICIDADE [Descritor de assunto]
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Id:27312
Autor:McDougall, A. Colin.
Título:Bacillary and histopathological findings in the peripheral nerves of armadillos experimentally infected with M. leprae.
Fonte:Int. J. Lepr;65(2):260-261, Jun. 1997. .
Descritores:Mycobacterium leprae/citol
Mycobacterium leprae/patogen
Nervos Periféricos/irrig
Nervos Periféricos/microbiol
Nervos Periféricos/patol
Limites:Animais
Localização:BR191.1


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Id:27303
Autor:Ponnighaus, Jorg M; Lienhardt, Christian; Lucas, Sebastian; Fine, Paul E. M; Sterne, Jonathan A. C.
Título:Comparison of bacillary indexes in slit-skin smears, skin and nerve biopsies; a study from Malawi.
Fonte:Int. J. Lepr;65(2):211-216, Jun. 1997. tab, graf.
Resumo:Data analyzed in this paper were collected within the framework of the Lepra Evaluation Project, an epidemiological study of leprosy in Karonga District, northern Malawi. For 212 patients information on the number of skin lesions, slit-skin smear and skin biopsy results were available. Among 61 patients with a single lesion none were slit-skin-smear positive and two had bacilli detected in skin biopsies. In contrast, among 119 patients with four or more lesions 34 (28.6%) versus 59 (49.6%) had bacilli detectable in slit-skin smears or skin biopsies, respectively. In a further 47 patients skin biopsy results could be compared with split-nerve biopsy results. In 20 of 47 patients the bacterial indexes (BIs) were identical in skin and nerve biopsies, while in 26 of 47 patients the BIs were higher in nerve than in skin biopsies. This difference, which is consistent with several other studies in the literature, provides an insight into the pathogenesis of leprosy. (AU)^ien.
Descritores:Hanseníase/epidemiol
Hanseníase/microbiol
Mycobacterium leprae/isol
Mycobacterium leprae/patogen
Limites:Humanos
Masculino
Feminino
Localização:BR191.1


  3 / 125 HANSEN  
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Id:27165
Autor:Solomon, Samuel; Kurian, Nisha; Ramadas, Palani; Rao, Pamidipai Samuel Simon Sudar.
Título:Incidence of nerve damage in leprosy patients treated with MDT.
Fonte:Int. J. Lepr;66(4):451-456, Dec. 1998. tab.
Resumo:The incidence rates of sensory and motor impairments during and after multidrug therapy (MDT) are reported for a prospective cohort of patients who had no nerve damage at registration (N = 1621). Sensory and motor loss increased with age and both were high among multibacillary patients as compared with paucibacillary patients. The lateral popliteal (common peroneal) and posterior tibial nerves seem to be most affected for sensory loss; whereas the posterior tibial and ulnar nerves are mainly responsible for motor loss. No significant difference by gender was found. Implications for prevention of disability (POD) activities are discussed and suitable recommendations made. (AU)^ien.
Descritores:Hanseníase/quimioter
Hanseníase/epidemiol
Hanseníase/fisiopatol
Mycobacterium leprae/patogen
Limites:Humanos
Masculino
Feminino
Adolescente
Meio Eletrônico:http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1998/pdf/v66n4/v66n4a02.pdf - en.
Localização:BR191.1


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Id:27128
Autor:Antia, Noshir H; Birdi, TJ.
Título:The macrophage in leprosy: a review on the current status.
Fonte:Int J Lepr;57(2):511-525, June 1989. .
Descritores:Mycobacterium leprae/isol
Mycobacterium leprae/patogen
Hanseníase/imunol
Meio Eletrônico:http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n2/v57n2edt.pdf - en.
Localização:Br191.1


  5 / 125 HANSEN  
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Id:27124
Autor:Marolia, Jolly; Mahadevan, PR.
Título:Reactive oxygen intermediates inactive Mycobacterium leprae in the phagocytes from human peripheral blood.
Fonte:Int J Lepr;57(2):483-491, June 1989. ^btab.
Resumo:Reactive oxygen intermediates such as hydrogen peroxide, superoxide, and hydroxyl radicals are important microbicidal components, and they could also play a role in an infection with Mycobacterium leprae. A comparative study of the level of hydrogen peroxide and superoxide produced by peripheral blood phagocytes from normal healthy individuals and lepromatous leprosy patients showed a deficiency in superoxide production in the patients. In the phagocytes from normal healthy individuals, there was good release of superoxide ions, and this mediated the killing of M. leprae. The lack of superoxide production allowed the viability of M. leprae inside the macrophages from leprosy patients. This deficiency could be rectified by the use of an immunomodulator, the delipidified cell wall of M. leprae. This modulation resulted in the ability of the patients' phagocytes to respond to M. leprae, to produce reactive oxygen intermediates such as superoxide, and also to kill the bacteria. These observations indicate that delipidified cell wall could have significant potential to positively modulate the immune-deficient cells of leprosy patients.^ien.
Descritores:Hanseníase Virchowiana/metab
Hanseníase Virchowiana/microbiol
Hanseníase Virchowiana/reabil
Mycobacterium leprae/imunol
Mycobacterium leprae/patogen
Superóxido Dismutase/bios
Superóxido Dismutase/metab
Meio Eletrônico:http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n2/v57n2a06.pdf - en.
Localização:Br191.1


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Id:26777
Autor:Ngamying, Maeya; Varachit, Paijit; Phaknilrat, Phanida; Levy, Louis; Brennan, Patrick J; Cho, Sang-Nae.
Título:Effects of vaccination with several mycobacterial proteins and lipoproteins on Mycobacterium leprae infection of the mouse.
Fonte:Int. J. Lepr;69(1):43-45, Mar., 2001. tab.
Descritores:Mycobacterium leprae/patogen
Micobactérias Atípicas/patogen
Lipoproteínas/fisiol
Limites:Animais
Camundongos
Meio Eletrônico:http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/2001/pdf/v69n1/v69n1cor05.pdf - en.
Localização:BR191.1


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Id:26112
Autor:Hadler, W. A.
Título:The action of electronegative colloidal particles on the inflammatory reaction induced by Mycobacterium leprae and M. lepraemurium in rats, guinea pigs and rabbits.
Fonte:Rev. bras. Leprol;27(1):9-14, jan.-mar. 1959. ^bilus.
Resumo:Estudou-se em ratos, cobaios e coelhos, a influência de partículas coloidais sôbre a estrutura das lesões produzidas por micobactérias. Suspensões de M. leprae, ou de M. lepraemurium, foram inoculadas concomitantemente com suspensões coloidais (azul da Prússia, azul de Tripan, ou carvão), nessas três espécies animais, por via intraperitoneal ou intradêrmica. As lesões formadas no local da inoculação e em vários órgãos foram estudadas histológicamante durante a evolução da reação inflamatória. No rato, as lesões provocadas pelas mistura de micobactérias e partículas elétro-negativas são mais intensas, mais localizadas e apresentam maior número de macrófagos, comparadas com as lesões dos animais controles, que recebem apenas micobactérias. Os macrófagos fagocitam os bacílos e atrocitam as partículas injetadas. Em algumas áreas das lesões há  indícios de lise dos bacílos e digestão das part¡culas, pelos macrófagos, o que ocorre nos animais contrôles. Nessas áreas, que são limitadas, os macrófagos após lisarem os bacílos se transformam em células de tipo epitelióide. Nessas circuntâncias, há  modificação do tipo de estrutura das lesões, porquanto aparecem áreas de aspecto tuberculóide no interior de lesões lepromatosas. No cobaio e no coelho, as partículas coloidais atuam em sentido oposto, tornando mais lenta a lise dos bacilos pelos macrófagos; como conseqüência a evolução das lesões é mais lenta. A estrutura histológica das lesões, no entanto, não é alterada. A modificação da estrutura das lesões, verificadas no rato inoculado com micobactérias em mistura com partículas elétronegativas, é provavelmente devida à ação estimulante dêsses dois elementos agindo conjuntamente; nestas circunstância, haveria ativação de sistemas enzímicos dos macrófagos, os quais seriam responsáveis pela lise das micobactérias. (AU)^ipt.
Descritores:Mycobacterium leprae/citol
Mycobacterium leprae/fisiol
Mycobacterium leprae/patogen
Mycobacterium lepraemurium/citol
Mycobacterium lepraemurium/metab
Mycobacterium lepraemurium/fisiol
Limites:Animais
Ratos
Meio Eletrônico:http://hansen.bvs.ilsl.br/textoc/revistas/brasleprol/1959/PDF/v27n1/v27n1a02.pdf - en.
Localização:BR191.1


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Texto Completo-pt
Id:25899
Autor:Miranda, R. N..
Título:A propósito de um caso de manifestação aguda da lepra: encontro de bacilos de Hansen incluídos em polimorfonucleares. Esboço clínico e patogênico das manifestações agudas, em lepromatosos.
Fonte:Rev. bras. Leprol;29(1):3-12, mar. 1961. ilus.
Resumo:O autor descreve um caso de lepra lepromatosa, que apresentou fenomenos agudos constituidos por febre, adenopatias, hiperleucocitose, etc., e lesões cutaneas eritema-necroticas, em cujo exsudato foram encontrados bacilos de Hansen, sob a forma de globias, incluidos em polimorfonucleares. O surto agudo durou trinta dias, depois do qual o doente restabeleceu-se, continuando a sofrer sua lepra lepromatosa crônica, da variedade clinica difusa, vindo a manifestar, posteriormente, novos surtos. Aproveita a ocorrência desse caso para recordar um trabalho de sua autoria, publicado em 1942("Manifestações agudas da Lepra" Tese, Fac. Med., Curitiba, 1942), no qual: 1-estudou os chamados estado de reação, na lepra, como resultatntes de um processo patogênico comum, devidos a própria doença, em exarcebação aguda; 2- denominou esses estados, genericamente, de MANIFESTAÇÕES AGUDAS DA LEPRA, com diversas variedades clinicas; 3- fes referência, mais de uma vez, ao encontro de bacilos de Hansen, em lepromatosos, sob a forma de globias ou não, fagocitados pelos polimorfonucleares, em exsudato daquelas lesões agudas que supurararm ou ulceraram; 4- admitiu que as lesões agudas dessas manifestações, no tipo L, não se processam apenas no tegmento, mas tambem nos nervos, nos gânglios, nas visceras; 5- referiu-se ao fato de que, quando essas manifestações chegam a supuração de suas lesões cutâneas, pproporcionam grande eliminação de bacilos e, consequentemente, beneficio para o enfermo.(AU)^ipt.
Descritores:Hanseníase/imunol
Hanseníase/microbiol
Hanseníase/fisiopatol
Mycobacterium leprae/citol
Mycobacterium leprae/fisiol
Mycobacterium leprae/patogen
Neutrófilos/microbiol
Neutrófilos/fisiol
Meio Eletrônico:http://hansen.bvs.ilsl.br/textoc/revistas/brasleprol/1961/PDF/v29n1/v29n1a01.pdf - pt.
Localização:BR191.1


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Id:25870
Autor:Hadler, W. A.
Título:Estudo comparado das lesões provocadas por suspensões de "M. leprae" e de "M. tuberculosis, injetadas por via intradêrmica, em cobaios préviamente vacinados pelo BCG / Comparative study of injuries caused by suspensions of "M. leprae" and of "M. tuberculosis, injected intradermally in guinea pigs previously vaccinated with BCG
Fonte:Rev. bras. Leprol;22(2):109-123, jun. 1954. ^btab.
Resumo:The lesions suspensions by intracutaneous injections of M. tuberculosis and M. leprosy suspensions, in BCG vaccinated guinea pigs, are cytologically alike; the cells of the inflmmatory tissue are morphologically and physiologically indicals and constitute lesions of a same type, with a central abscess surrounded by the tuberculosis inflammatory tissue. This cytological and histological identity makes easy the comparative study of the lesions by these two mycobacteria in vaccinated guinea pigs. In opposition in normal guinea pigs the same comparison is difficulted by the presence of the abscess observed only animals injected with M. tuberculosis. Ninety eight normal guinea pigs were innoculated with 33.0 mg of BCG, by peritoneal or intramuscular route. Fourt days after 58 guineas pigs were injected intracutaneously with 0,05 ml of a M. tuberculosis (BCG) suspension, containing 0.165 mg of bacilli; 22 guinea pigs were injected by this same via with 0, 1 ml of lepromin contaning nearly 0.074 mg of M. leprae; the other 20 guinea pigs were injected by this same route with 0.165 mg of BCG on a side and with 0,1 ml of lepromin containing 0.170 mg of M. leprae on the other side. The macroscopic and microscopic lesions suscitated by the intracutaneous injection of these two mycobacteria were observed during 50 days. The macroscopic examination shows: a) the reaction provoked by 0.165 mg of BCG is stronger but disappears at the 30th day after innoculation; b) the reaction suscitated by approximately 0.074 mg of M. leprae is weaker but vanishes only 40days after innoculation. The histological study of the lesions shows: a) the injection of 0.165 mg of BCG induces stronger reactions which have shorter evolutive course, with complete cicatrization of the 50th day; b) the injection of nearly 0.170 mg of M. leprae produces weaker lesions which have longer evolutive course, without complete cicatrization at the 50th day after innoculation. The evolutive speed of the... (AU)^ien.
Descritores:Mycobacterium leprae/genet
Mycobacterium leprae/fisiol
Mycobacterium leprae/patogen
Mycobacterium tuberculosis/genet
Mycobacterium tuberculosis/fisiol
Mycobacterium tuberculosis/patogen
Pele/citol
Pele/les
Limites:Animais
Meio Eletrônico:http://hansen.bvs.ilsl.br/textoc/revistas/brasleprol/1954/PDF/v22n2/v22n2a01.pdf - pt.
Localização:BR191.1


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Id:25862
Autor:Marani, Angela Messias
Título:Análise da apoptose induzida pelo Mycobacterium Leprae em células mononucleares de pacientes com formas polares de Hanseníase
Analysis of apoptosis induced by Mycobacterium leprae in mononuclear cells of patients with polar forms of leprosy-
Fonte:Bauru; s.n; 2008. 49 p. ilus, graf.
Descritores:Hanseníase Virchowiana/microbiol
Hanseníase Virchowiana/virol
Hanseníase Tuberculóide/microbiol
Hanseníase Tuberculóide/virol
Mycobacterium leprae/citol
Mycobacterium leprae/genet
Mycobacterium leprae/patogen
Apoptose/fisiol
Limites:Humanos
Masculino
Feminino
Localização:BR191.1; WC335.400, M825a


  11 / 125 HANSEN  
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Texto Completo-pt
Id:25849
Autor:Cerqueira, Gil de Castro.
Título:Eliminação do bacillo de Hansen pela via cutânea / Elimination of Hansen's Bacillo by cutis
Fonte:Rev. Lepr. São Paulo;2(2):87-92, 1935. .
Descritores:Hanseníase/microbiol
Hanseníase/fisiopatol
Hanseníase/parasitol
Hanseníase/virol
Mycobacterium leprae/metab
Mycobacterium leprae/fisiol
Mycobacterium leprae/patogen
Meio Eletrônico:http://hansen.bvs.ilsl.br/textoc/revistas/leprolsp/1935/PDF/v2n2/v2n2a02.pdf - pt.
Localização:Br191.1


  12 / 125 HANSEN  
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Id:25770
Autor:Rodrigues, J; Mabalay, E; Tolentino, J. C.
Título:Formas Gram-positivas de M. leprae de lesões leproticas bacteriologicamente negativas para organismos acido-resistentes / Gram-positive forms of M. Leprae leprous lesions of bacteriologically negative for acid-resistant organisms
Fonte:Rev. Lepr. São Paulo;1(2):111-121, Jan. 1934. ^btab.
Resumo:1) Pelo emprego do metodo de Much é possivel demonstrar a presença de formas gram-positivas de M. leprae numa percentagem consideravel de lesões leproticas que não contem bacilos acido resistentes. 2) Que muitos destes bacilos anacido-resistentes n„o s„o puramente formas degeneradas pode-se julgar do fato que s„o numerosas em muitos casos dos chamados fechados, incipientes que não sofreram tratamento (AU)^ipt.
Descritores:Mycobacterium leprae/citol
Mycobacterium leprae/metab
Mycobacterium leprae/fisiol
Mycobacterium leprae/patogen
Meio Eletrônico:http://hansen.bvs.ilsl.br/textoc/revistas/leprolsp/1934/PDF/v1n2/v1n2a06.pdf - pt.
Localização:BR191.1


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Id:25745
Autor:Hansen, G. A
Título:Études sur la bacterie de la lèpre
Studies on the leprosy bacterium-
Fonte:s.l; s.n; 1882. 11 p. .
Resumo:La question de la contagiosit‚ de la lèpre n'a pas frait de progres dans ces dernières ann‚es, malgr‚ les travaux de Neisser (1) et Kubner (2). (AU)^ifr.
Descritores:HANSENIASE/microbiol
HANSENIASE/fisiopatol
HANSENIASE/parasitol
HANSENIASE/transm
HANSENIASE/virol
MYCOBACTERIUM LEPRAE/citol
MYCOBACTERIUM LEPRAE/cresc
MYCOBACTERIUM LEPRAE/fisiol
MYCOBACTERIUM LEPRAE/patogen
Localização:BR191.1; 01054/d.a


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Texto Completo-pt
Id:25711
Autor:Lowe, John.
Título:Repetição dos exames dos casos de lepra / Repetition of examinations of cases of leprosy with high
Fonte:Rev. Lepr. São Paulo;1(1):28-30, Set. 1933. ^btab.
Descritores:Hanseníase/diag
Hanseníase/microbiol
Hanseníase/patol
Hanseníase/fisiopatol
Hanseníase/virol
Mycobacterium leprae/cresc
Mycobacterium leprae/isol
Mycobacterium leprae/metab
Mycobacterium leprae/patogen
Meio Eletrônico:http://hansen.bvs.ilsl.br/textoc/revistas/leprolsp/1933/PDF/v1n1/v1n1a06.pdf - pt.
Localização:BR191.1


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Id:25679
Autor:Truman, Richard; Fontes, Amanda B; Miranda, Antonio B. de; Suffys, Philip; Gillis, Thomas
Título:Genotype variation and stability of four variable-number tandem repeats and their suitability for discriminating strains of Mycobacterium leprae
..-
Fonte:s.l; s.n; 2004. 8 p. tab.
Resumo:It has not been possible to distinguish different strains of Mycobacterium leprae according to their genetic sequence. However, the genonme contais several variable-number tandem repeats (VNTR), which have been used effectively in strain typing of other bacteria. To determine their suitability for differentiating M. leprae, we developed PCR systems to amplify 5 different VNTR loci and examined a battery of 12 M. leprae strains derived from patients in different regions of the United States, Brazil, Mexico, and the Philippines, as well as from wild armadillos and sooty mangabey monkey. We found diversity at for VNTR (D = 0.74), butone system (C16G8) failed to yield reproducible results. Alleles for the GAA VNTR varied in length from 9 to 12 copies, andthose for AT17 varied in length from 13 to 20 copies. Relatively little variation was seen with interspecies transfer of bacilli or during short-term passage of strains in nude mice or armadillos. The TA18 locus was more polymorphic than other VNTR, and genotypic variation was more common after long-term expansion in armadillos. Most strain genotypes remained fairly stable in passage, but atrain Thai-53 showed reamrkable any particular genotype associable with different regions or hosts of origen. VNTR polymorphisms can be used effectively to discriminate M. leprae strains. Inclusion of additional loci and other elements will likely lead to robust typing system that can be used in community-based epidemiological studies and select clinical application (AU)^ien.
Descritores:Mycobacterium leprae/genet
Mycobacterium leprae/imunol
Mycobacterium leprae/metab
Mycobacterium leprae/fisiol
Mycobacterium leprae/patogen
Hanseníase/imunol
Hanseníase/virol
Limites:Humanos
Localização:BR191.1; 09253/s


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Id:25517
Autor:Portugal, H
Título:Presença de bacilos de hansen e de lesões especificas nas papilas da polpa digital, em leprosos sem lesões locais aparentes
Presence of bacilli, hansen and injuries in specific papillae of digital pulp, a local lepers without apparent injuries-
Fonte:s.l; s.n; 1934. 8p p. .
Descritores:MYCOBACTERIUM LEPRAE/citol
MYCOBACTERIUM LEPRAE/imunol
MYCOBACTERIUM LEPRAE/fisiol
MYCOBACTERIUM LEPRAE/patogen
PELE/les
Limites:ESTUDO COMPARATIVO
Localização:BR191.1; 01743/s


  17 / 125 HANSEN  
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Id:25458
Autor:Ebenezer, G. J; Norman, G; Joseph, G. A; Daniel, S; Job, C. K
Título:Drug resistant-Mycobacterium leprae- results of mouse footpad studies from a laboratory in South India
..-
Fonte:s.l; s.n; 2002. 12 p. tab.
Resumo:Out of 265 biopsies of leprosy patients received at the Experimental Laboratory of Schieffelin Leprosy Research and Training Centre from 1987 to 1997 for evaluating resistant strains of M. leprae using the mouse footpad technique, 49 showed resistant strains of M. leprae to varying concentration of dapsone, rifampicin and clofazimine. 23 (47%) of these were from a control area. With 369 skin-smear positive multibacillary (MB) patients as the risk group (denominator), 23 (6.23%) were resistant to one or more drugs. 18 (4.88%) had dapsone resistance, 5 (1.36%) were resistant to rifampicin and 9 (2.44%) had resistance to low concentrations of clofazimine (0.0001%). Out of the 23 biopsies with drug resistance from the control area, primary dapsone resistance was seen in 7 (30%) biopsies and secondary dapsone resistance in 11 (48%). Primary rifampicin resitance was seen in 4 (17.4%) patients, secondary rifampicin resistance in 1 (4.35%) and primary clofazimine resistance in 7 (30%). 3 (13%) of the strains showed secondary clofazimine resistance. One biopsy had resistent strains to all the three drugs. In a control area where properly supervised effective multidrug therapy (MDT) was regularly administered over the years, the emergence of drug resistance is negligible. It may not be the case if the content, duration and regularity of the drug regimen were not satisfactory. Aware of the possible shortcomings in mass administration of MDT, it is emplasized that mouse footpad studies on drug resistance should be made available at least in endemic areas where the incidence of the disease has not changed despite good MDT coverage in order to monitor the emergence of drug resistance. Research into molecular biological identification of drug resistant-M.leprae should be intensified. These steps would help to institute timely measures to check the spread of any drug-resistant organisms in the community (AU).
Descritores:MYCOBACTERIUM LEPRAE/cresc
MYCOBACTERIUM LEPRAE/isol
MYCOBACTERIUM LEPRAE/metab
MYCOBACTERIUM LEPRAE/patogen
MYCOBACTERIUM LEPRAE/ultraest
RESISTÊNCIA A DROGAS
DAPSONA/uso terap
CLOFAZIMINA/uso terap
RIFAMPINA/uso terap
TESTES DE SENSIBILIDADE MICROBIANA/métodos
TESTES DE SENSIBILIDADE MICROBIANA/vet
HANSENIASE/clas
 HANSENIASE/compl
 HANSENIASE/quimioter
 HANSENIASE/imunol
 HANSENIASE/microbiol
 HANSENIASE/patol
 OFLOXACINO/uso terap
 MINOCICLINA/uso terap
Limites:HUMANO
Localização:BR191.1; 09299/s


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Id:25457
Autor:Rambukkana, Anura
Título:Mycobacterium leprae-induced demyelination: a model for early nerve degeneration
..-
Fonte:s.l; s.n; 2004. 7 p. ilus.
Resumo:The molecular events that occur at the early phase of many demyelinating neurodegenerative diseases are unknown. A recent demonstratation of rapid demyelination and axonal injury induced by Mycobacterium leprae provides a model for elucidating the molecular events of early nerve degeneration which might be common to neurodegenerative diseases of both infectious origin and unknown etiology. The identification of the M. leprae-targeted Schwann cell receptor, dystroglycan, and its associated molecules in myelination, demyelination and axonal functions suggests a role for these molecules in early nerve degeneration (AU).
Descritores:DOENCAS DESMIELINIZANTES/etiol
DOENCAS DESMIELINIZANTES/imunol
DOENCAS DESMIELINIZANTES/microbiol
DOENCAS DESMIELINIZANTES/patol
MYCOBACTERIUM LEPRAE/quim
MYCOBACTERIUM LEPRAE/cresc
MYCOBACTERIUM LEPRAE/patogen
DEGENERACAO NEURAL/etiol
 DEGENERACAO NEURAL/patol
 HANSENIASE/compl
 HANSENIASE/imunol
 HANSENIASE/microbiol
 HANSENIASE/patol
Limites:HUMANO
Localização:BR191.1; 09300/s


  19 / 125 HANSEN  
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Id:25445
Autor:Monot, Marc; Honore, Nadine; Garnier, Thierry; Araoz, Romulo; Coppee, Jean-Yves; Lacroix, Celine; Sow, Samba; Spencer, John S; Truman, Richard W; Williams, Diana L; Gelber, Robert; Virmond, Marcos; Flageul, Beatrice; Cho, Sang-Nae; Ji, Baohong; Paniz-Mondolfi, Albertp; Convit, Jacinto; Young, Saroj; Fine, Paul E; Rasalofo, Voahangy; Brennan, Patrick J; Cole, Stewart T
Título:On the origin of leprosy
..-
Fonte:s.l; s.n; 2005. 3 p. ilus, mapas, tab, graf.
Resumo:Leprosy, a chronic human disease with potentially debilitating neurological consequences, results from infection with Mycobacterium leprae. This unculturable pathogen has undergone extensive reductive evolution, with half of its genome now occupied by pseudogenes. Using comparative genomics, we demonstrated that all extant cases of leprosy are attributable to a single clone whose dissemination wordwide can be retraced from analysis of very rare single-nucleotide polymorphisms. The disease seems to have originated in Easterm Africa or the Near East and spread with successive human migrations. Europeans or North Africans introduced leprosy into West Africa and the Americas within the past 500 years (AU).
Descritores:Mycobacterium leprae/genetica
Mycobacterium leprae/patogenicidade
Hanseniase/etiologia
 Hanseniase/historia
Limites:IN VITRO
Localização:BR191.1; 09308/s


  20 / 125 HANSEN  
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Id:25437
Autor:Velasco, Felix
Título:Tuberculoid leprosy - its transformation into lepromatous type
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Fonte:s.l; s.n; 1940. 16 p. ilus, tab.
Resumo:A brief review of the contradictory opinions of different authors as to the nature and the place of tuberculoid cases of leprosy in the evolution and pathogenesis of the disease is presented. Mention is also made of their failure to agree on what could be generally considered as the esential histological features of this condition. A case of tuberculoid leprosy which has undergone transformation into a lepromatous-type case within six years of observation is presented. This case report together with the clinical, bacteriological and histological studies of other authors seem to agree with the opinion of Manalang that tuberculoid leprosy is a stage in the evolution of leprosy, not immutable as assert by Schujman. That such transformation among adult tuberculoid cases is rare because they represent the filtered resistant ones or benign infections, is indicated. The need for continued follow-up and life-long study of contact children born of leper parents in institutions is indispensable if we are to know the evolution of leprosy. (AU).
Descritores:HANSENIASE VIRCHOWIANA/compl
HANSENIASE VIRCHOWIANA/diag
HANSENIASE VIRCHOWIANA/microbiol
HANSENIASE VIRCHOWIANA/patol
HANSENIASE TUBERCULOIDE/compl
HANSENIASE TUBERCULOIDE/diag
HANSENIASE TUBERCULOIDE/microbiol
HANSENIASE TUBERCULOIDE/patol
HANSENIASE/clas
HANSENIASE/compl
HANSENIASE/diag
HANSENIASE DIMORFA/compl
 HANSENIASE DIMORFA/diag
 MYCOBACTERIUM LEPRAE/citol
 MYCOBACTERIUM LEPRAE/imunol
 MYCOBACTERIUM LEPRAE/patogen
Limites:RELATO DE CASO
Localização:BR191.1; 00661/s



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